Decreased Vascular Density in Mouse Pancreatic Islets After Transplantation

Decreased vascular density in mouse pancreatic islets after transplantation.

An adequate revascularization is crucial for islet survival and function after transplantation. Previous studies have suggested that islet revascularization is concluded within 14 days after transplantation. We investigated if the vascular density of transplanted islets and endogenous pancreatic islets differs. Cultured islets were syngeneically transplanted into the kidney, liver, or spleen of...

Isolated Mouse Pancreatic Islets

Inosine is a potent primary stimulus of insulin secretion from isolated mouse islets. The inosine-induced insulin secretion was totally depressed during starvation, but was completely restored by the addition of 5mmi-caffeine to the medium and partially restored by the addition of 5mM-glucose. Mannoheptulose (3mg/ml) potentiated the eflect of lOmM-inosine in islets from fed mice. The mechanism ...

An artificial transplantation site for pancreatic islets.

Magnetic Resonance Imaging of Pancreatic Islets Transplantation

pH is decreased in transplanted rat pancreatic islets

Carlsson, Per-Ola, Astrid Nordin, and Fredrik Palm. pH is decreased in transplanted rat pancreatic islets. Am J Physiol Endocrinol Metab 284: E499–E504, 2003. First published November 5, 2002; 10.1152/ajpendo.00156.2002.—Recent studies of transplanted pancreatic islets have indicated incomplete revascularization. We investigated the pH, in relation to oxygen tension (PO2), in endogenous islets ...